Using Jojoba oil and wax in the beauty industry is no longer a surprise for anybody. The properties of jojoba seeds are numerous, and its usage is widely spread.
Taking that into consideration, there were scientists who wonder how much more the benefic potential of jojoba can be extended in this area, so a study called Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model has been launched (link at the end of the article).
This study investigated the anti-inflammatory effects of jojoba wax and its impact on extracellular component synthesis through topical application. Analyzing fatty acid profiles and other components, researchers used a human skin organ culture model to assess the wax's effects. Results showed that jojoba wax reduced key pro-inflammatory cytokines by approximately 30% and increased pro-collagen and hyaluronic acid synthesis. The findings suggest jojoba wax effectively reduces skin inflammation and enhances extracellular matrix components, potentially aiding in age-related skin issues.
Most studies on jojoba's dermo-cosmetic properties rely on in-vitro data, which lacks clinical relevance. Using an ex-vivo human skin model allows for evaluating both topical applications and their clinical effects. This study aimed to assess jojoba wax's anti-inflammatory activities and its impact on extracellular component synthesis. Skin tissues were obtained from healthy female donors (ages 40-65) during elective abdominal surgeries with informed consent. The study was approved by the IRB of Soroka Medical Center, adhering to Helsinki declaration guidelines. It highlights the strong anti-inflammatory effects and significant boost in ECM component synthesis after treatment with both natural and emulsified jojoba wax. Additionally, it presents an accessible, low-cost method for preparing stable emulsions on a small scale in the lab.
This study introduces several novel findings, including that adding an emulsifier to jojoba wax doubles its anti-inflammatory effects, which may have commercial potential. Additionally, the observed ECM remodeling, along with increased collagen III and hyaluronic acid synthesis, is a new discovery, aligning with past research on collagen I in jojoba-treated fibroblasts. Demonstrating these effects on human skin further validates jojoba wax's medicinal properties. However, limitations like the absence of blood circulation and systemic immune response in the skin organ culture model suggest that further clinical studies are needed to fully understand its active compounds and therapeutic potential.
Nevertheless, it was once again demonstrated that using jojoba oil benefits the skin, enhancing the likelihood of naturally boosting collagen III and hyaluronic acid production.
Bibliography : https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1333085/full